Dr. Mark Janik

Teaching Interests

Organic Chemistry, Medicinal Chemistry, Advanced Organic Chemistry and General Chemistry

Research Interests

Organic Synthesis and Medicinal Chemistry (Development of Anti-Cancer Compounds)



Selected Publications

1. Soumyananda Chakraborti, Lalita Das, Neha Kapoor, Amlan Das, Vishnu Dwivedi,

Asim Poddar, Gopal Chakraborti, Mark Janik, Gautam Basu, Dulal Panda, Pinak

Chakrabarti, Avadhesha Surolia,and Bhabatarak Bhattacharyya; “Curcumin

Recognizes a Unique Binding Site of Tubulin” J. Med. Chem., 2011, 54(18), pp.6183-

6196.



2. Lalita Das, Suvroma Gupta, Dipak Dasgupta, Asim Poddar, Mark E. Janik,

BhabatarakBhattacharyya; “Bindingof Indanocine to the Colchicine Site on Tubulin

Promotes Fluorescence, and Its Binding Parameters Resemble Those of the

Colchicine Analogue AC” Biochemistry, 2009, 48 (7), pp 1628–1635.



3. Michael Cifuentes, Brett Schilling, Rudy Ravindra, Jacquelyn Winter and Mark E.

Janik*; “Synthesis and Biological Evaluation of B-ring Modified Colchicine and

Isocolchicine Analogs” Bioorg. Med. Chem. Lett., 2006, 16(10); 2761-2764.



4. Gupta, S.; Das, L.; Datta, A. B.; Poddar, A.; Janik, M. E.; Bhattacharyya, B.;

"Oxalone and Lactone Moieties of Podophyllotoxin Exhibit Properties of Both the

B and C Rings of Colchicine in Its Binding with Tubulin" Biochemistry; 2006;

45(20); 6467-6475.



5. Potenziano, J., Spitale, R & Janik, M.E.; "IMPROVED AND HIGHLY VERSATILE

SYNTHESIS OF 5-ARYLTROPONES" Synth. Commun., 2005, 35(15), 2005-2016.



6. Lalita Das, Ajit B. Datta, Suvroma Gupta, Asim Podder, Suparna Sengupta,Mark E.

Janik*, Bhabatarak Bhattacharyya*; "-NH-Dansyl Isocolchicine Exhibits a

Significantly Improved Tubulin Binding Affinity and Microtubule Inhibition in

Comparison to Isocolchicine by Binding Tubulin Through its A and B

ring."Biochemistry, 2005, 44(9), 3249-3258.



7. Janik, M.E. & Bane, S.L. (2002). “Synthesis and Antimicrotubule Activity of

Combretatropone Derivatives” Bioorg. Med. Chem. 10, 1895-1903.